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KMID : 0352819880040010013
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Kosin Medical Journal
1988 Volume.4 No. 1 p.13 ~ p.19
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RENAL CORTICAL Na-K-ATPase IN CADMIUM-INTOXICATAED RATS
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Kim Y.K.
Park Y.S.
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Abstract
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Changes in sodium, potassium-activated adenosinetriphosphatase (Na-K-ATPase) activity was studied in renal cortical microsomes of cadmium-intoxicated rats. Cadmium-into)dcation was induced by sub-cutaneous inje -tions of CdC12 dissolved in saline at a dose of 2 mg Cd/kg day for 16 days. The Na-K-ATPase activity was determined at the end of 4th and 16th day of treatment and 20 days after treatment ceased, and the values were compared with those observed in matched control (saline-treated) animals. The enzyme activity was not significantly altered after 4 days of Cd-treatment, but it was markedly reduced after 16 days of the treatment (35.4 f 3.2(SE) m moles Pi/g protein per hr as opposed to 56.73.0 in the control). During 20 days of recovery period the enzyme activity was considerably reverted. These results are discussed in relation to changes in renal transport of Na´, glucose, and p-aminohippurate in cadmium-intoxicated animals.
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KEYWORD
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